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Article

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

The Journal of clinical investigation - 1 Dec 1995

Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak L P

Abstract excerpt

The brown fat-specific mitochondrial uncoupling protein (UCP) provides a mechanism for generating heat by uncoupling respiration and oxidative phosphorylation. It has been suggested that this system of thermogenesis can provide a defense against obesity. To test this idea, we created a transgenic...

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Identifiers

PMID: 8675663
DOI: 10.1172/JCI118363
PMCID: PMC186003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8675663-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.PMID 8675663Read ↗

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