Article
High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content.
The Journal of biological chemistry - 8 Nov 2002
Couplan Elodie, Gelly Chantal, Goubern Marc, Fleury Christophe, Quesson Bruno, Silberberg Mathieu, Thiaudiere Eric, Mateo Philippe, Lonchampt Michel, Levens Nigel, De Montrion Catherine, Ortmann Silvia, Klaus Susanne, Gonzalez-Barroso Maria-Del-Mar, Cassard-Doulcier Anne-Marie, Ricquier Daniel, Bigard A Xavier, Diolez Philippe, Bouillaud Frederic
Abstract excerpt
The mitochondrial uncoupling protein of brown adipose tissue (UCP1) was expressed in skeletal muscle and heart of transgenic mice at levels comparable with the amount found in brown adipose tissue mitochondria. These transgenic mice have a lower body weight, and when related to body weight, food intake and energy expenditure are increased. A specific reduction of muscle mass was observed but varied according to...
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