Article
Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone.
Molecular genetics and metabolism - 1 Dec 2012
Martens Katrin, Bottelbergs Astrid, Peeters Annelies, Jacobs Frank, Espeel Marc, Carmeliet Peter, Van Veldhoven Paul P, Baes Myriam
Abstract excerpt
Peroxisomes are essential for intermediary lipid metabolism, but the role of these organelles has been primarily studied in the liver. We recently generated aP2-Pex5 conditional knockout mice that due to the nonselectivity of the aP2 promoter, not only had dysfunctional peroxisomes in the adipose tissue but also in the central and peripheral nervous system, besides some other tissues. Peroxisomes were however...
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