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Article

Longitudinal analysis of the effect of apolipoprotein E epsilon4 and education on cognitive performance in elderly subjects: the PAQUID study.

Journal of neurology, neurosurgery, and psychiatry - 1 Jun 2002

Winnock M, Letenneur L, Jacqmin-Gadda H, Dallongeville J, Amouyel P, Dartigues J F

Abstract excerpt

BACKGROUND: The apolipoprotein E (apoE) epsilon4 allele has been shown to be a risk factor for dementia, but it is not clear to what extent apoE affects overall cognitive function in non-demented elderly subjects, or how this risk may be modified by gene-environment interactions. OBJECTIVE: To examine changes in cognitive function in elderly people as a function of the apoE epsilon4 phenotype. METHODS: A...

Topics

Aged
Aged, 80 and over
Apolipoproteins E
Cognition Disorders
Cohort Studies
Educational Status
Female
Humans
Longitudinal Studies
Male
Mental Status Schedule

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Risk Factors

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Identifiers

PMID: 12023428
DOI: 10.1136/jnnp.72.6.794
PMCID: PMC1737928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12023428-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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