Article

Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice

1992-06-01

Abstract excerpt

CRF is released in response to various stressors and regulates ACTH secretion and glucocorticoid production. CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome. To test whether CRF overproduction leads to Cushing's syndrome and to develop an animal model of chronic pituitary-adrenal activation, the CRF gene was expressed under...

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Literature Corpus work: f154178f-4082-5c8b-ac96-a890b0bc814e
DOI: 10.1210/en.130.6.3378

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