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Article

Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress.

Psychoneuroendocrinology - 1 May 2011

Wagner Klaus V, Wang Xiao-Dong, Liebl Claudia, Scharf Sebastian H, Müller Marianne B, Schmidt Mathias V

Abstract excerpt

The incidence of chronic stress is frequently related to the development of psychiatric disorders like depression. The hypothalamic-pituitary-adrenal (HPA) axis is a major physiological system that mediates the stress response. Tight HPA axis regulation through negative feedback mechanisms is essential for health and environmental adaptation. This feedback regulation acts in part through the glucocorticoid...

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Source

Identifiers

PMID: 20940090
DOI: 10.1016/j.psyneuen.2010.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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