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Article

Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations.

BMC infectious diseases - 7 May 2002

Duffy Karen E, Quail Matthew R, Nguyen Tammy T, Wittrock Robert J, Bartus Joan O, Halsey Wendy M, Leary Jeffry J, Bacon Teresa H, Sarisky Robert T

Abstract excerpt

BACKGROUND: The thymidine kinase (tk) mutagenesis assay is often utilized to determine the frequency of herpes simplex virus (HSV) replication-mediated mutations. Using this assay, clinical and laboratory HSV-2 isolates were shown to have a 10- to 80-fold higher frequency of spontaneous mutations compared to HSV-1. METHODS: A panel of HSV-1 and HSV-2, along with polymerase-recombinant viruses expressing type 2...

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Identifiers

PMID: 12019036
DOI: 10.1186/1471-2334-2-7
PMCID: PMC113270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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