Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.

Journal of virology - 1 Jul 1994

Pyles R B, Thompson R L

Abstract excerpt

The contribution of the herpes simplex virus type 1 (HSV-1)-encoded uracil DNA glycosylase (UNG), thymidine kinase (TK), and dUTPase to the relative mutant frequency (RMF) of the virus in cultured murine cells was examined. A panel of HSV-1 mutants that lacked singly or doubly the UNG, TK, or dUTPase activity were generated by disruption of the enzyme coding regions with the Escherichia coli beta-galactosidase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to DNA Replication
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetics

Share to Mutation

Share to Rabbits

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 8207826
DOI: 10.1128/JVI.68.7.4514-4524.1994
PMCID: PMC236378

Genes

UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.PMID 8207826Read ↗

Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latencySemantic proximity Read ↗

DNA sequence of mutations induced in cells by herpes simplex virus type-1.Semantic proximity Read ↗

Thymidine kinase of herpes simplex virus type 1 strain KOS lacks mutator activity.Semantic proximity Read ↗

Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations.Semantic proximity Read ↗

Herpes simplex virus mutant generation and dual-detection methods for gaining insight into latent/lytic cycles in vivo.Semantic proximity Read ↗

Roles of uracil-DNA glycosylase and dUTPase in virus replicationSemantic proximity Read ↗

Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous systemSemantic proximity Read ↗

Mutation of the herpes simplex virus 1 KOS UL45 gene reveals dose dependent effects on central nervous system growth.Semantic proximity Read ↗

Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations.Semantic proximity Read ↗

Difference in incidence of spontaneous mutations between Herpes simplex virus types 1 and 2.Semantic proximity Read ↗

Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis.Semantic proximity Read ↗

Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.