Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.

doi:10.1128/JVI.68.7.4514-4524.1994

Article

Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.

Journal of virology - 1 Jul 1994

Pyles R B, Thompson R L

Abstract excerpt

The contribution of the herpes simplex virus type 1 (HSV-1)-encoded uracil DNA glycosylase (UNG), thymidine kinase (TK), and dUTPase to the relative mutant frequency (RMF) of the virus in cultured murine cells was examined. A panel of HSV-1 mutants that lacked singly or doubly the UNG, TK, or dUT...

Topics

3T3 Cells
Animals
Cells, Cultured
DNA Glycosylases
DNA Replication
DNA, Viral
Herpesvirus 1, Human
Kinetics
Mice
Mutation
N-Glycosyl Hydrolases
Pyrophosphatases
Rabbits
Thymidine Kinase
Uracil-DNA Glycosidase
Virus Replication
beta-Galactosidase

Mutations in accessory DNA replicating functions alter the relative mutation frequency of herpes simplex virus type 1 strains in cultured murine cells.

Abstract excerpt

Topics

Discuss the evidence