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Article

Thymidine kinase of herpes simplex virus type 1 strain KOS lacks mutator activity.

Virology - 20 Jan 2003

Hwang Ying T, Wang Y-A, Lu Q, Hwang Charles B C

Abstract excerpt

The effect of thymidine kinase (TK) encoded by herpes simplex virus type 1(HSV-1) strain KOS in DNA replication fidelity was examined by two different mutagenesis assays. Mutagenesis assay of the LacZ reporter gene present in recombinant tkLTRZ1, which contained the integrated LacZ gene in the tk locus, revealed a less than 0.05% mutation frequency of the LacZ gene regardless of whether the viruses were...

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Identifiers

PMID: 12573584
DOI: 10.1006/viro.2002.1776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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