Article
An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase.
Gene - 23 Jan 1995
Hwang C B, Chen H J
Abstract excerpt
The mutation spectrum attributable to an antimutator DNA polymerase in a eukaryotic cell was examined. Drug-resistant thymidine kinase (tk) mutants derived from both a wild-type (wt) strain, KOS and an antimutator DNA polymerase (pol) mutant, PAAr5, of herpes simplex virus (HSV), were isolated, and the mutated tk genes were characterized at the sequence level. While both transition and frameshift mutations were...
Topics
- Antimutagenic Agents
- Base Sequence
- DNA, Viral
- DNA-Directed DNA Polymerase
- Molecular Sequence Data
- Mutation
- Simplexvirus
- Thymidine Kinase