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Article

The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein.

Genes & development - 15 Apr 1994

Flickinger T W, Salz H K

Abstract excerpt

Alternative splicing controls the expression of many genes, including the Drosophila sex determination gene Sex-lethal. Previous studies have suggested that snf plays a role in regulating Sex-lethal splicing. Here, we demonstrate that snf is an integral component of the machinery required for splice site recognition. We have cloned snf and found that it has sequence homology to the mammalian U1A and U2B" snRNP...

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PMID: 7926776
DOI: 10.1101/gad.8.8.914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein.PMID 7926776Read ↗

Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development.Semantic proximity Read ↗

The Drosophila sex determination gene snf is utilized for the establishment of the female-specific splicing pattern of Sex-lethal.Semantic proximity Read ↗

The Drosophila U2 snRNP protein U2A' has an essential function that is SNF/U2B" independent.Semantic proximity Read ↗

SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The survival motor neuron gene smn-1 interacts with the U2AF large subunit gene uaf-1 to regulate Caenorhabditis elegans lifespan and motor functions.Semantic proximity Read ↗

Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo.Semantic proximity Read ↗

Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf(+) gene dose effects.Semantic proximity Read ↗

The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes.Semantic proximity Read ↗

The chromatin remodeling and mRNA splicing functions of the Brahma (SWI/SNF) complex are mediated by the SNR1/SNF5 regulatory subunit.Semantic proximity Read ↗

PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila.Semantic proximity Read ↗

Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.Semantic proximity Read ↗

spenito is required for sex determination in Drosophila melanogaster.Semantic proximity Read ↗

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