Article
Endothelin-1 gene polymorphism in the identification of patients at risk for malignant ventricular arrhythmia.
Medical science monitor : international medical journal of experimental and clinical research - 1 May 2002
Kozák Milan, Hollá Lýdie Izákovicova, Krivan Lubomír, Vasků Anna, Sepsi Milan, Borivoj Semrád, Vácha Jirí
Abstract excerpt
BACKGROUND: The endothelins are peptides with vasoconstricting and growth-promoting properties. Endothelin-1 (ET-1) is known for its direct positive inotropic and chronotropic effects on isolated heart, and for growth effects. The aim of this pilot study was to investigate the frequency distribution of a common polymorphism of the endothelin (ET-1) gene and its possible relation to the hemodynamic consequences of...
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