Prognostic relevance of β1-adrenergic receptor polymorphisms on cardiovascular outcome in patients treated with metoprolol after acute myocardial infarction - an observational study.

Abstract excerpt

PURPOSE: To investigate the association between β1-adrenergic receptor (ADRB1) polymorphisms on cardiovascular events in patients treated with metoprolol after acute myocardial infarction (AMI). METHODS: Patients hospitalized for AMI (n = 1584) who were treated with metoprolol at discharge were genotyped for the ADRB1 variants Arg389Gly and Ser49Gly. The association between the ADRB1 variants and major adverse...

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