Article
Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients.
Experimental and molecular pathology - 1 Jun 2008
Spinarová L, Spinar J, Vasků A, Pávková-Goldbergová M, Ludka O, Tomandl J, Vítovec J
Abstract excerpt
The study objective is to prove an association among plasma concentration of big endothelin and endothelin-1, other clinical parameters and two frequent polymorphisms - G8002A and -3A/-4A - in the endothelin-1 (EDN-1) coding gene (6p21-23), and among plasma concentration of TNF alpha and gene polymorphisms TNF alpha -308 A/G, -238 A/G, TNF beta Ncol and 3'TACE (tumour necrosis factor alpha converting enzyme) in...
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