Article
Endothelin-1 gene polymorphism in patients with malignant arrhythmias.
Journal of cardiovascular pharmacology - 1 Nov 2004
Kozák Milan, Izákovicová Hollá Lýdie, Krivan Lubomír, Vasků Anna, Sepsi Milan, Semrád Borivoj, Vácha Jirí
Abstract excerpt
The endothelins are peptides with vasoconstricting and growth-promoting properties. Endothelin-1 (ET-1) is known with its direct positive inotropic and chronotropic effects on isolated heart and with growth effects. The aim of this pilot study was to investigate the frequency distribution of the common polymorphism of the ET-1 gene and its possible relation with hemodynamic consequences of malignant ventricular...
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