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Article

Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.

Nature cell biology - 1 Apr 2007

Trenker Michael, Malli Roland, Fertschai Ismene, Levak-Frank Sanja, Graier Wolfgang F

Abstract excerpt

Mitochondrial Ca(2+) uptake is crucial for the regulation of the rate of oxidative phosphorylation, the modulation of spatio-temporal cytosolic Ca(2+) signals and apoptosis. Although the phenomenon of mitochondrial Ca(2+) sequestration, its characteristics and physiological consequences have been...

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Identifiers

PMID: 17351641
DOI: 10.1038/ncb1556
PMCID: PMC4060164

Genes

UCP2
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17351641-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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