Article
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.
Nature cell biology - 1 Apr 2007
Trenker Michael, Malli Roland, Fertschai Ismene, Levak-Frank Sanja, Graier Wolfgang F
Abstract excerpt
Mitochondrial Ca(2+) uptake is crucial for the regulation of the rate of oxidative phosphorylation, the modulation of spatio-temporal cytosolic Ca(2+) signals and apoptosis. Although the phenomenon of mitochondrial Ca(2+) sequestration, its characteristics and physiological consequences have been convincingly reported, the actual protein(s) involved in this process are unknown. Here, we show that the uncoupling...
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