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Article

The antioxidant function of Bcl-2 preserves cytoskeletal stability of cells with defective respiratory complex I.

Cellular and molecular life sciences : CMLS - 1 Sept 2008

Porcelli A M, Ghelli A, Iommarini L, Mariani E, Hoque M, Zanna C, Gasparre G, Rugolo M

Abstract excerpt

Human thyroid carcinoma XTC.UC1 cells harbor a homoplasmic frameshift mutation in the MT-ND1 subunit of respiratory complex I. When forced to use exclusively oxidative phosphorylation for energy production by inhibiting glycolysis, these cells triggered a caspase-independent cell death pathway, which was associated to a significant imbalance in glutathione homeostasis and a cleavage of the actin cytoskeleton....

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Identifiers

PMID: 18695940
DOI: 10.1007/s00018-008-8300-2
PMCID: PMC11131887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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