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Article

alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2002

Montgomery David E, Wolska Beata M, Pyle W Glen, Roman Brian B, Dowell Jasmine C, Buttrick Peter M, Koretsky Alan P, Del Nido Pedro, Solaro R John

Abstract excerpt

Protein kinase C (PKC)-mediated phosphorylation of cardiac myofilament (MF) proteins has been shown to depress the actomyosin interaction and may be important during heart failure. Biochemical studies indicate that phosphorylation of Ser(43) and Ser(45) of cardiac troponin I (cTnI) plays a substantial role in the PKC-mediated depression. We studied intact and detergent-extracted papillary muscles from...

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Identifiers

PMID: 12003851
DOI: 10.1152/ajpheart.00714.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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