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Article

Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.

Circulation research - 4 Dec 2009

Kirk Jonathan A, MacGowan Guy A, Evans Caroline, Smith Stephen H, Warren Chad M, Mamidi Ranganath, Chandra Murali, Stewart Alexandre F R, Solaro R John, Shroff Sanjeev G

Abstract excerpt

RATIONALE: Protein kinase (PK)C-induced phosphorylation of cardiac troponin (cTn)I has been shown to regulate cardiac contraction. OBJECTIVE: Characterize functional effects of increased PKC-induced cTnI phosphorylation and identify underlying mechanisms using a transgenic mouse model (cTnI(PKC-P)) expressing mutant cTnI (S43E, S45E, T144E). METHODS AND RESULTS: Two-dimensional gel analysis showed 7.2+/-0.5%...

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Identifiers

PMID: 19850940
DOI: 10.1161/CIRCRESAHA.109.205427
PMCID: PMC2862555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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