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Article

Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Oct 2003

Burkart Eileen M, Arteaga Grace M, Sumandea Marius P, Prabhakar Rethinasamy, Wieczorek David F, Solaro R John

Abstract excerpt

A region of interaction between the near N-terminal of cardiac troponin I (cTnI) and the C-lobe of troponin C (cTnC), where troponin T (cTnT) binds, appears to be critical in regulation of myofilament Ca(2+)-activation. We probed whether functional consequences of modulation of this interface influence the function of tropomyosin (Tm) in thin filament activation. We modified the C-lobe of cTnC directly by...

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Identifiers

PMID: 14519438
DOI: 10.1016/s0022-2828(03)00240-2

Genes

EMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathy.PMID 14519438Read ↗

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