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Article

Identification of two new regions in the N-terminus of cardiac troponin T that have divergent effects on cardiac contractile function.

The Journal of physiology - 1 Mar 2013

Mamidi Ranganath, Mallampalli Sri Lakshmi, Wieczorek David F, Chandra Murali

Abstract excerpt

Abstract Cardiac troponin T (cTnT) has a highly acidic extended N-terminus, the physiological role of which remains poorly understood. To decipher the physiological role of this unique region, we deleted specific regions within the N-terminus of mouse cTnT (McTnT) to create McTnT1-44 and McTnT45-74 proteins. Contractile function and dynamic force-length measurements were made after reconstituting the McTnT...

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Source

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Identifiers

PMID: 23207592
DOI: 10.1113/jphysiol.2012.243394
PMCID: PMC3607867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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