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Article

Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury.

The American journal of pathology - 1 May 2002

Souza Danielle G, Soares Adriana C, Pinho Vanessa, Torloni Humberto, Reis Luiz F L, Teixeira Mauro M, Dias Adriana A M, Martins Mauro T

Abstract excerpt

TSG-14/PTX3 is a gene inducible by tumor necrosis factor (TNF)-alpha, interleukin-1 beta, and lipopolysaccharide in fibroblasts, macrophages, and endothelial cells. It encodes a 42-kd secreted glycoprotein that belongs to the pentraxin family of acute-phase proteins. Recently, we demonstrated that TSG-14 transgenic mice (TSG-14tg) overexpressing the murine TSG-14 gene under control of its own promoter are more...

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Identifiers

PMID: 12000727
DOI: 10.1016/s0002-9440(10)61122-4
PMCID: PMC1850862

Genes

TNF
PTX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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