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Article

Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.

Shock (Augusta, Ga.) - 1 Apr 2008

Rajan Saju, Vyas Dinesh, Clark Andrew T, Woolsey Cheryl A, Clark Jessica A, Hotchkiss Richard S, Buchman Timothy G, Coopersmith Craig M

Abstract excerpt

Targeted IL-10 therapy improves survival in preclinical models of critical illness, and intestine-specific IL-10 decreases inflammation in models of chronic Inflammatory disease. We therefore sought to determine whether intestine-specific overexpression of IL-10 would improve survival in sepsis. Transgenic mice that overexpress IL-10 in their gut epithelium (Fabpi-IL-10 mice) and wild-type (WT) littermates (n =...

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Identifiers

PMID: 17998890
DOI: 10.1097/shk.0b013e31815bbb26
PMCID: PMC2562881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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