Article
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.
The Journal of experimental medicine - 17 Nov 2003
Kano Arihiro, Wolfgang Michael J, Gao Qian, Jacoby Joerg, Chai Gui-Xuan, Hansen William, Iwamoto Yoshiki, Pober Jordan S, Flavell Richard A, Fu Xin-Yuan
Abstract excerpt
Endothelial cells (ECs) are believed to be an important component in the protection from lipopolysaccharide (LPS)-induced endotoxic shock. However, the cellular and molecular mechanism is not well defined. Here, we report that signal transducer and activator of transcription (STAT) 3 is an essent...
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