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Article

HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury.

American journal of physiology. Gastrointestinal and liver physiology - 1 Oct 2010

Feinman Rena, Deitch Edwin A, Watkins Anthony C, Abungu Billy, Colorado Iriana, Kannan Kolenkode B, Sheth Sharvil U, Caputo Francis J, Lu Qi, Ramanathan Madhuri, Attan Shirhan, Badami Chirag D, Doucet Danielle, Barlos Dimitrios, Bosch-Marce Marta, Semenza Gregg L, Xu Da-Zhong

Abstract excerpt

Acute lung injury (ALI) and the development of the multiple organ dysfunction syndrome (MODS) are major causes of death in trauma patients. Gut inflammation and loss of gut barrier function as a consequence of splanchnic ischemia-reperfusion (I/R) have been implicated as the initial triggering ev...

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Source

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Identifiers

PMID: 20689059
DOI: 10.1152/ajpgi.00065.2010
PMCID: PMC2957330

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20689059-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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