Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock.

Journal of the American College of Surgeons - 1 Mar 2006

Prince Jose M, Levy Ryan M, Yang Runkuan, Mollen Kevin P, Fink Mitchell P, Vodovotz Yoram, Billiar Timothy R

Abstract excerpt

BACKGROUND: Hemorrhagic shock and resuscitation (HS/R) activates inflammatory pathways leading to organ injury after trauma. Toll-like receptors (TLRs), such as TLR4, are required for activation of proinflammatory cellular signaling pathways in response to microbial products, but can also recognize endogenous molecules released from damaged tissues. Using mouse strains deficient in TLR4 protein or signaling, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine Transaminase
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-10

Share to Interleukin-6

Share to Liver Diseases

Share to Mice, Inbred C3H

Share to Nitric Oxide Synthase

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 16500244
DOI: 10.1016/j.jamcollsurg.2005.11.021

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock.PMID 16500244Read ↗

TLR4 influences the humoral and cellular immune response during polymicrobial sepsis.Semantic proximity Read ↗

Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3.Semantic proximity Read ↗

Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor.Semantic proximity Read ↗

The Toll-like receptors and their role in septic shockSemantic proximity Read ↗

Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network.Semantic proximity Read ↗

Role of the complement in experimental sepsisSemantic proximity Read ↗

Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic miceSemantic proximity Read ↗

Toll-like receptor signaling in sepsisSemantic proximity Read ↗

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia.Semantic proximity Read ↗

Nonhematopoietic toll-like receptor 2 contributes to neutrophil and cardiac function impairment during polymicrobial sepsis.Semantic proximity Read ↗

MKK4 knockdown plays a protective role in haemorrhagic shock-induced liver injury through the JNK pathwaySemantic proximity Read ↗

Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.