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Article

Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice.

Scientific reports - 18 Nov 2015

Gao Yu-Lei, Chai Yan-Fen, Dong Ning, Han Su, Zhu Xiao-Mei, Zhang Qing-Hong, Yao Yong-Ming

Abstract excerpt

The primary mechanisms of sepsis induced cellular immunosuppression involve immune dysfunction of T lymphocytes and negative immunoregulation of regulatory T cells (Tregs). It has been found that tuftsin is an immune modulating peptide derived from IgG in spleen. T-peptide is one of tuftsin analogs. Herein, we examined the effect of T-peptide on cell-mediated immunity in the presence of lipopolysaccharide (LPS)...

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Source

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Identifiers

PMID: 26577833
DOI: 10.1038/srep16725
PMCID: PMC4649719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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