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Article

Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock.

Journal of leukocyte biology - 1 Nov 2004

Cuzzocrea Salvatore, Nocentini Giuseppe, Di Paola Rosanna, Mazzon Emanuela, Ronchetti Simona, Genovese Tiziana, Muià Carmelo, Caputi Achille P, Riccardi Carlo

Abstract excerpt

In the present study, we used glucocorticoid-induced tumor necrosis factor (TNF) receptor family gene knockout (GITR-KO) mice to evaluate a possible role of GITR on the pathogenesis of splanchnic artery occlusion (SAO) shock, which was induced in mice by clamping the superior mesenteric artery and the celiac artery for 30 min, followed thereafter by release of the clamp (reperfusion). At 60 min after reperfusion,...

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PMID: 15316036
DOI: 10.1189/jlb.0204110

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TNF

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