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Article

Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates.

The Journal of allergy and clinical immunology - 1 May 2002

Mapp Cristina E, Fryer Anthony A, De Marzo Nicoletta, Pozzato Valeria, Padoan Michele, Boschetto Piera, Strange Richard C, Hemmingsen Anja, Spiteri Monica A

Abstract excerpt

BACKGROUND: Polymorphism at the pi class glutathione-S-transferase locus (GSTP1) is associated with allergen-induced asthma and related phenotypes. OBJECTIVE: We sought to determine whether GSTP1 polymorphism influences susceptibility to asthma induced by toluene diisocyanate (TDI). METHODS: The role of GSTP1 was assessed in 131 workers exposed to TDI, 92 with TDI-induced asthma and 39 asymptomatic subjects. The...

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Source

Identifiers

PMID: 11994713
DOI: 10.1067/mai.2002.123234

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates.PMID 11994713Read ↗

Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma.Semantic proximity Read ↗

The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.Semantic proximity Read ↗

Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma.Semantic proximity Read ↗

Glutathione-S-transferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma.Semantic proximity Read ↗

Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study.Semantic proximity Read ↗

The HLA DRB1*1501-DQB1*0602-DPB1*0501 Haplotype Is a Risk Factor for Toluene Diisocyanate-Induced Occupational AsthmaSemantic proximity Read ↗

Genetics of occupational asthma.Semantic proximity Read ↗

Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.Semantic proximity Read ↗

Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure.Semantic proximity Read ↗

Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57.Semantic proximity Read ↗

Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate.Semantic proximity Read ↗

N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk.Semantic proximity Read ↗

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