Article
The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.
Pharmacogenetics and genomics - 1 Feb 2010
Broberg Karin E, Warholm Margareta, Tinnerberg Håkan, Axmon Anna, Jönsson Bo A, Sennbro Carl Johan, Littorin Margareta, Rannug Agneta
Abstract excerpt
BACKGROUND: Toluene di-isocyanate (TDI) is widely used in the production of polyurethane foams and paints. As TDI causes respiratory disease in only a fraction of exposed workers, genetic factors may play a key role in disease susceptibility. Polymorphisms in TDI metabolising genes may affect elimination kinetics, resulting in differences in body retention, and in its turn differences in adverse effects....
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