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Article

Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.

The Journal of clinical endocrinology and metabolism - 1 May 2002

Knauf Jeffrey A, Ward Laura S, Nikiforov Yuri E, Nikiforova Marina, Puxeddu Efisio, Medvedovic Mario, Liron Tamar, Mochly-Rosen Daria, Fagin James A

Abstract excerpt

PKC isozymes are the major binding proteins for tumor-promoting phorbol esters, and PKC activity is abnormal in a number of different human cancers. Less is known about putative structural and functional changes of specific PKC isozymes in human neoplasms. A single-point mutation of PKCalpha at position 881 of the coding sequence has been observed in human pituitary adenomas and up to 50% of thyroid follicular...

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PMID: 11994357
DOI: 10.1210/jcem.87.5.8441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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