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Article

Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.

Cancer research - 1 May 2006

Zhang Lin, Huang Jia, Yang Nuo, Liang Shun, Barchetti Andrea, Giannakakis Antonis, Cadungog Mark G, O'Brien-Jenkins Ann, Massobrio Marco, Roby Katherine F, Katsaros Dionyssios, Gimotty Phyllis, Butzow Ralf, Weber Barbara L, Coukos George

Abstract excerpt

The protein kinase C (PKC) family plays a key regulatory role in a wide range of cellular functions as well as in various cancer-associated signal transduction pathways. Here, we investigated the genomic alteration and gene expression of most known PKC family members in human ovarian cancer. The DNA copy number of PKC family genes was screened by a high-resolution array-based comparative genomic hybridization in...

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PMID: 16651413
DOI: 10.1158/0008-5472.CAN-05-4527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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