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Article

Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.

The Journal of clinical endocrinology and metabolism - 1 Feb 1998

Ringel M D, Saji M, Schwindinger W F, Segev D, Zeiger M A, Levine M A

Abstract excerpt

Activating mutations of the TSH receptor and alpha-subunit of Gs (G alpha s) that increase adenylyl cyclase activity have been identified in a subset of hyperfunctioning benign thyroid follicular adenomas and, less commonly, in hypofunctioning adenomas and carcinomas. In addition some thyroid tumors exhibit inappropriate activation of phospholipase C (PLC), a signaling pathway that has been implicated in the...

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Source

Identifiers

PMID: 9467574
DOI: 10.1210/jcem.83.2.4536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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