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Article

Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations.

The Biochemical journal - 15 Nov 2010

Durgan Joanne, Parker Peter J

Abstract excerpt

Fbw7 (F-box WD40 protein 7) is a major tumour suppressor, which mediates the degradation of several potent oncogenes. PKC (protein kinase C) comprises a serine/threonine kinase family that can promote transformation when dysregulated. In the present study, we investigated the relationship between Fbw7 and PKC. Multiple members of the PKC superfamily interact with the substrate-binding domain of Fbw7. However, we...

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Identifiers

PMID: 20815813
DOI: 10.1042/BJ20100799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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