Clinical features and pathobiology of neurofibromatosis 1.

Abstract excerpt

Neurofibromatosis 1 is a progressive multisystem disorder. The hallmark feature is the occurrence of nerve sheath tumors, neurofibromas. Other features include tumors such as optic gliomas and malignant peripheral nerve sheath tumors. There are also nontumor manifestations, such as skeletal dysplasia and learning disabilities. Since the NF1 gene was identified, much has been learned about the molecular genetics...

Topics

• Cell Transformation, Neoplastic
• Child
• Gene Expression
• Genes, Neurofibromatosis 1
• Humans
• Neurofibromatosis 1
• Phenotype