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Article

Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors.

Neuropharmacology - 1 Apr 2002

Krupp Johannes J, Vissel Bryce, Thomas Christopher G, Heinemann Stephen F, Westbrook Gary L

Abstract excerpt

Phosphatase IIb (calcineurin, CaN) can reduce N-methyl-D-aspartate (NMDA) synaptic responses by enhancing glycine-independent desensitization. We examined the action of CaN on desensitization in recombinant NMDA receptors comprised of NMDA receptor 1 (NR1) and NR2A subunits. The C-terminus of NR2A, but not NR1, was critical for modulation of desensitization by CaN. Alanine-scanning mutagenesis indicated that...

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Identifiers

PMID: 11985816
DOI: 10.1016/s0028-3908(02)00031-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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