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Article

PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits.

Journal of neurochemistry - 1 Mar 2005

Jones Michelle L, Leonard John P

Abstract excerpt

Insulin modulates N-methyl-d-aspartate (NMDA) receptors in the CNS and potentiates currents of recombinant NMDA receptors in a subunit-specific manner in Xenopus oocytes. Previously we identified two sites in the NR2B C-terminus as targets for direct phosphorylation by C-type protein kinases (PKCs). Mutating these sites reduced insulin potentiation of currents by one half, reflecting the PKC-mediated portion of...

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Source

Identifiers

PMID: 15748161
DOI: 10.1111/j.1471-4159.2004.02985.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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