Article
Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study.
BMC neurology - 4 Oct 2011
Zuliani Giovanni, Donnorso Michela Perrone, Bosi Cristina, Passaro Angelina, Dalla Nora Edoardo, Zurlo Amedeo, Bonetti Francesco, Mozzi Alessia F, Cortese Claudio
Abstract excerpt
BACKGROUND: In central nervous system cholesterol cannot be degraded but is secreted into circulation predominantly in the form of its polar metabolite 24(S)-hydroxycholesterol (24S-OH-Chol). Some studies suggested an association between 24S-OH-Chol metabolism and different neurological diseases including dementia. A possible decrease in 24S-OH-Chol plasma levels has been reported late onset Alzheimer's disease...
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