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Article

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.

Journal of lipid research - 1 May 2011

Shafaati Marjan, Marutle Amelia, Pettersson Hanna, Lövgren-Sandblom Anita, Olin Maria, Pikuleva Irina, Winblad Bengt, Nordberg Agneta, Björkhem Ingemar

Abstract excerpt

There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from the circulation across the blood-brain barrier. Because there is a correlation between 27OHC and cholesterol in the circulation and lipoprotein-bound cholesterol does not pass the blood-brain barrier, we have suggested that 27OHC may mediate the effects of hypercholesterolemia on the brain. We previously demonstrated a...

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Identifiers

PMID: 21335619
DOI: 10.1194/jlr.M014548
PMCID: PMC3073459

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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