Article
Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo.
Stem cells (Dayton, Ohio) - 1 Feb 2017
Morales-Garcia Jose A, Echeverry-Alzate Victor, Alonso-Gil Sandra, Sanz-SanCristobal Marina, Lopez-Moreno Jose A, Gil Carmen, Martinez Ana, Santos Angel, Perez-Castillo Ana
Abstract excerpt
The phosphodiesterase 7 (PDE7) enzyme is one of the enzymes responsible for controlling intracellular levels of cyclic adenosine 3',5'-monophosphate in the immune and central nervous system. We have previously shown that inhibitors of this enzyme are potent neuroprotective and anti-inflammatory agents. In addition, we also demonstrated that PDE7 inhibition induces endogenous neuroregenerative processes toward a...
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