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Article

The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2012

Kwakowsky Andrea, Herbison Allan E, Ábrahám István M

Abstract excerpt

The mechanisms through which estradiol (E2) regulates gonadotropin-releasing hormone (GnRH) neurons to control fertility are unclear. Previous studies have demonstrated that E2 rapidly phosphorylates cAMP response element-binding protein (CREB) in GnRH neurons in vivo. In the present study, we used GnRH neuron-specific CREB-deleted mutant mice [GnRH-CREB knock-outs (KOs)] with and without global cAMP response...

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Source

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Identifiers

PMID: 22895714
DOI: 10.1523/JNEUROSCI.1333-12.2012
PMCID: PMC6621199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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