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Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Stamatakou Eleanna, Zhu Ye, Rubinsztein David C

Abstract excerpt

The accumulation of mutant aggregate-prone proteins is a hallmark of the majority of neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases. Autophagy, a cytosolic bulk degradation system, is the major clearance pathway for several aggregate-prone proteins, such as mutant huntingtin. The autophagosome-associated protein LC3-II is a specific marker of autophagic flux within...

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PMID: 29856012
DOI: 10.1007/978-1-4939-7825-0_2

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