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Article

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Pieper A A, Brat D J, Krug D K, Watkins C C, Gupta A, Blackshaw S, Verma A, Wang Z Q, Snyder S H

Abstract excerpt

Streptozotocin (STZ) selectively destroys insulin-producing beta islet cells of the pancreas providing a model of type I diabetes. Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme whose overactivation by DNA strand breaks depletes its substrate NAD+ and then ATP, leading to cellular death from energy depletion. We demonstrate DNA damage and a major activation of PARP in pancreatic islets of STZ-treated...

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Identifiers

PMID: 10077636
DOI: 10.1073/pnas.96.6.3059
PMCID: PMC15894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.PMID 10077636Read ↗

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