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Article

Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer's disease.

Neuroreport - 16 Apr 2002

Münch Gerald, Shepherd Claire E, McCann Heather, Brooks William S, Kwok John B J, Arendt Thomas, Hallupp Marianne, Schofield Peter R, Martins Ralph N, Halliday Glenda M

Abstract excerpt

The most frequently mutated gene resulting in dominantly inherited Alzheimer's disease is presenilin-1. We have used antibodies against advanced glycation endproducts (AGE) in brain tissue sections of four patients with three different presenilin I mutations. Accumulation of intracellular AGE was observed in 75-95% of pyramidal neurons in patients with presenilin-1 mutations, far exceeding the percentage of...

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Identifiers

PMID: 11973454
DOI: 10.1097/00001756-200204160-00013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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