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Article

Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.

Neuroscience - 1 Jan 2004

Nakajima M, Shirasawa T

Abstract excerpt

Presenilin-1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. To probe the functions of PS1 on neuronal resistance to oxidative stress, we pharmacologically examined the death signals in PS1-deficient neurons induced by oxidative stress. Because the death of primarily cultured neurons lacking PS1 is caused by hydrogen peroxide in calcium-dependent manners in vitro [J...

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Identifiers

PMID: 15099670
DOI: 10.1016/j.neuroscience.2004.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.PMID 15099670Read ↗

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