Article
Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes.
Neuroscience letters - 29 Jan 1999
Takahashi H, Mercken M, Honda T, Saito Y, Murayama M, Song S, Takashima A
Abstract excerpt
Many cases of early-onset familial Alzheimer's disease (FAD) are caused by mutations in the presenilin 1 (PS1) and PS2 genes. PS1 protein is generated as a 47 kDa protein and is endoproteolytically cleaved into N-terminal 28 kDa and C-terminal 19 kDa fragments in vivo. To examine whether mutated PS1 protein is abnormally metabolized, we performed immunoblot analysis of lymphoblasts from familial Alzheimer's...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.