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Article

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

Nature medicine - 1 Jul 1997

Lee M K, Borchelt D R, Kim G, Thinakaran G, Slunt H H, Ratovitski T, Martin L J, Kittur A, Gandy S, Levey A I, Jenkins N, Copeland N, Price D L, Sisodia S S

Abstract excerpt

Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes can cause Alzheimer's disease in affected members of the majority of early-onset familial Alzheimer's disease (FAD) pedigrees. PS1 encodes an ubiquitously expressed, eight transmembrane protein. PS1 is endoproteolytically processed...

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PMID: 9212102
DOI: 10.1038/nm0797-756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9212102-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.PMID 9212102Read ↗

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