Article
Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.
Neuroreport - 6 May 1997
Hendriks L, Thinakaran G, Harris C L, De Jonghe C, Martin J J, Sisodia S S, Van Broeckhoven C
Abstract excerpt
Mutations in the presenilin genes are involved in the aetiology of the majority of familial early-onset Alzheimer disease (AD) cases. Presenilin 1 (PS1) is proteolytically processed in vivo, resulting in the accumulation of N-terminal approximately 27-28 kDa and C-terminal approximately 18 kDa derivatives. To examine the metabolism of PS1 in brains of patients with AD harbouring PS1 mutations I143T and G384A, we...
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