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Article

Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice.

Free radical biology & medicine - 1 Mar 2006

Schuessel Katrin, Frey Claudia, Jourdan Claudia, Keil Uta, Weber Claudia C, Müller-Spahn Franz, Müller Walter E, Eckert Anne

Abstract excerpt

Mutations in the presenilins (PS) account for the majority of familial Alzheimer disease (FAD) cases. To test the hypothesis that oxidative stress can underlie the deleterious effects of presenilin mutations, we analyzed lipid peroxidation products (4-hydroxynonenal (HNE) and malondialdehyde) and antioxidant defenses in brain tissue and levels of reactive oxygen species (ROS) in splenic lymphocytes from...

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Identifiers

PMID: 16520237
DOI: 10.1016/j.freeradbiomed.2005.10.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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