Article

Absence of the CHEK2 c.1100delC mutation in familial breast and ovarian cancer in Colombia: a case-control study

2018-07-09

Abstract excerpt

<h4>Background: </h4> BRCA1 and BRCA2 have been identified as high-penetrance breast cancer predisposition genes, but they only account for a small fraction of the inherited component of breast cancer. To explain the remaining cases, a polygenic model with a large number of low- to moderate-penetrance genes have been proposed; one of these, is the CHEK2 gene (Checkpoint Kinase 2). The objective of this study was...

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Literature Corpus work: 3ab2ebcc-750d-5ae3-8930-97e72141d4d2
DOI: 10.12688/f1000research.13368.1

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Absence of the CHEK2 c.1100delC mutation in familial breast and ovarian cancer in Colombia: a case-control studyDOI 10.12688/f1000research.13368.1Read

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